First of all, for Motherboard related questions, kindly post your questions in our Motherboards' community.
Now for a quick answer to your question, I would need to ask you if you are using the USB keyboards & mice. And do the two devices mentioned stop working even at Pre-Boot? If yes, you might want to ensure that if you are connecting them to front-panel USB header, the front-panel USB cables on board are connected & if at the back, you might want to look into the support page for the motherboard here.
You can post your queries further in case of any discrepancy in our Motherboard community as mentioned above.
Thank you for using Intel, have a great day!
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We are using USB keyboards and mice connected to the PS/2 connectors via adapters on the back of the computer. I have tried a PS/2 keyboard with the same results. The keyboard and mouse "lock-up" as soon as you press any key on the keyboard.