First of all, for Motherboard related questions, kindly post your questions in our Motherboards' community.
Now for a quick answer to your question, I would need to ask you if you are using the USB keyboards & mice. And do the two devices mentioned stop working even at Pre-Boot? If yes, you might want to ensure that if you are connecting them to front-panel USB header, the front-panel USB cables on board are connected & if at the back, you might want to look into the support page for the motherboard here.
You can post your queries further in case of any discrepancy in our Motherboard community as mentioned above.
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