Yes, you can. But I don't understand why on Earth you would ever want to. It's extremely easy to load a Windows ISO onto a USB flash drive, and install is MUCH faster.
Follow the instructions here:
You just need to download the Media Creation Tool from that link. Run that app on any computer and it will download a 32bit or 64bit copy of Windows 10 (choose 64bit), and load it onto a USB drive for you.
If you have a valid Product Key for any version of Windows 7/8/8.1, you can use that key during installation of Windows 10, and you will not have to purchase a new copy of Windows 10. It is a free upgrade.
If you do not have a valid previous version key, then yes you will need to purchase a new copy of Win 10, but the above tool can still be used for easier installations.
At what point are you having problems? Is this after you install Windows, or during installation?
A big annoyance with these NUC's (and most newer machines) is that the LAN driver isn't automatically installed with Win 10. You'll need to use another machine to download that to a flashdrive, copy over to the NUC and install. After you get that installed, Windows Update should find everything else.
Thanks for asking, answer is yes, more or less. It took me awhile to get it working. I am still having trouble with some drivers, I am using the intel driver update utility and several of the drivers the utility says I need never load. I get a failed to load, tried many times? I also tried updating the bios with bios update tool, it also never works. I get network connection in the bios but it still does not work. Any help would be appreciated. Thank you
I fully recommend downloading the appropriate drivers individually and installing yourself. You can get all you need here:
Be sure to select "Drivers" in the first menu, and Windows 10 x64 in the second menu.
The best order to install is usually this way:
2) RAID (even if not using a RAID configuration - it still contains the proper AHCI drivers)
3) Intel ME
7) Anything else
As for the BIOS update, download this and run from within Windows:
If you are using an M2 drive, you will need to go back into the BIOS settings to enable that after updating.