Please access the BIOS and press F9 on your keyboard to set the BIOS to the default settings select yes and then press F10 to save the changes and try again.
If that does not help, please try accessing the BIOS uncheck UEFI and make sure only legacy boot is checked, also I recommend doing a fresh operating system installation just make sure in the BIOS under devices in the USB tab the xHCI is disabled so you can use the mouse and keyboard while you’re installing Windows, then press F10 to save the changes.
Since this is not yet answered I'm going to jump in cause I am having the same issue. I am a sys admin for a dealership and we have several NUC5i3RYK's in use that I have purchased over the past 3 months. This issue has happened to a couple of the NUC's we have. It starts when the computer will boot up to a black screen with no mouse. I have been able to save most of them by re-applying an image that I have saved when setting these up however I am now in the same situation with two of them. Here is current info:
Transcend 64Gb SSd
Crucial 4Gb DDR4 RAM
Tried SSD in another known good unit, works fine
Tried booting to USB for both Acronis 2013 as well as Linux Mint 17 (all USB's show in the BIOS as "UEFI : HL-DT-STDVDRAM", normally shows as "General UDisk")
Set BIOS to default
Tried with legacy boot disabled
the M.2 SSD does show in the BIOS (Part 0 : OS Bootloader)
Getting error: A bootable device has not been detected.
After chatting with support the resolution has been to replace both units but since this is a re-occurring thing I am reaching out to the community for advice. These computers are in use every day and taking the time to send the unit in and wait for replacement is bad for business....
Just checking – is your BIOS version 0355?
I understand that you tried this SSD in another system and it is working fine… by any chance, are you able to try a different model of SSD with these units?
Do you have the Model number for the SSD you are using?
Please see the SSDs tested with this Intel® NUC at the following link:
These tested products work OK with this Intel® NUC, is it possible for you to try one of those?
Honestly I don’t see on the list a M.2 Transcend 64 GB SSD and maybe this can be some compatibility problem but the best way to know if this is true is to try one of the SSDs listed on the tested peripherals.
BIOS was updated and is currently on 0355.
I've also tried a Samsung SSD which gave the same issue, however it's not listed on the tested devices. The model that I used is: MZ-N5E120 Samsung SSD 850 EVO.
When I tried the SSD in another device it was the exact same NUC model that had the same BIOS and RAM installed, not to say that it's a sure fire way of telling but it's something.
I will see about getting one of the tested SSD's and next time this happens, (with the track record I've had with these its only a matter of time) I will try using one those and see what happens.