I have two thoughts:
- If you have been attempting to do this with UEFI disabled, try enabling it. Some of the new video boards do not include a legacy BIOS driver any longer and UEFI boot is necessary.
- Some of the new boards require that the motherboard offer specific capabilities to work. For example, some boards require PCIe v3.0, which your board (because of its age) doesn't have.
If the system responds fine when using an specific card but it does not work with other card we can consider that as a compatibility issue, also bear in mind that your motherboard does not support Windows 10 so we cannot guarantee that it will work as expected. You can also follow the suggestions provided by Scott on this same forum, those are good thoughts that definitely can be considered based on your problem but again, if the issue happens with specific hardware that seems to be a compatibility problem.
If you need more help please let us know.