Hello chris2807, how would you describe the noise you are getting?
Can you provide the Intel® NUC’s model and speakers you are using?
I think it can be a feedback noise caused by the microphone, if you have any one connected. Try turning the microphone off, turning down the volume, or moving the speakers away from the system and see if the noise disappears.
Another possibility is that the noise is caused by a bad wire connection or grounding issue. Try to connect all devices to a grounded power strip.
I fixed the issue with a ground loop isolator. It costs around 10$. All the problems gone