Tony, we have seen this behavior on NUCs but once the Infrared (CIR) driver is installed on the system, the error disappears.
In your case could be something else, since the DC53427HYE does not come with this feature.
Remember that it is very important to install all drivers in order, starting with the chipset driver (.INF), graphics, audio and then management engine.
I found this link regarding this behavior, please check it out http://www.driverscape.com/download/intel(r)-8-series-lpc-controller-(premium-sku)---9c43
You can also try installing the CIR driver. Please choose the operating system you are using and give it a try.
Did you install a mini-card WiFi adapter? If so, be sure to install the wireless drivers (and Bluetooth, if it includes that). You can find the links here:
I have come across similar (Unknown Device on QS77 Express Chipset LPC Controller - 1E53) error and noticed that if I unchecked Trusted Platform Module and its presence from bios then it didn't show in the device manager and there will be no unknown device in the device manager. My configuration is NUC DC53427HYE and I am using Windows Embedded System 7. I hope this will help others as well.
Tag: Unknown Device on NUC DC53427HYE, TPM, TPM not presence.