What is the model of the NUC you are getting? What type of device are you planning on connecting to the IR interface in that system?
I'm getting the i5 (Haswell) version ...NUC D54250WYK2.
I'm would like to use Logitech Harmony Ultimate (with hub).
But I guess I should have some software installed on the NUC to handle the infrared?
As mentioned on the technical product specification (TPS) of that system, customers are required to provide their own media center compatible remote or smart phone application for use with the Intel NUC. Therefore any hardware or software is to be provided by Logitech in that case.