Try removing your SoundBlaster ZXR then reload BIOS to default, then after try setting the BIOS to whichever values you want all without the SoundBlaster ZXR and see if this helps.
Daniel82, please follow the suggestion given by stephenb.b.r and let us know the results.
In addition to that you can try removing the CMOS battery and leave the system without it for about an hour. Then, put it back on and restart the computer.
Thanks for the help Stephen and Sylvia,
I tried both of your suggestions and also tried the card in different pcix slots and still the issue persisted. I have since swapped to a asus sabertooth board and this has resolved my issues. Also it resolved an issue where on the intel board I had no rpm fan speeds reported (using corsair AF & SP fans) I now have these being reported with the asus board.
Shame as I think the intel board had slightly smoother performance with sli enabled. So yes this does appear to be a faulty board. Thanks again for your help.