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I have the same problem with a 2008 model DX38BT Bone Trail Extreme Intel board.
The first time I installed a Nvidia GTX 280 video card.
The machine wouldn't boot. /keyboard locked.. can't get into bios..
I took the card out and installed my old vid card.
Then I went to intel for a newer bios.And it FIXED it.
Now the GTX 280 is working fine. with a new bios.
Now I bought a new BFG FX 295 the newest fastest card dual GPU card.
Now again I have the same problem with the machine not booting and it sits there.
BIOS is locked ..NO boot, Keyboad is locked. And this card is incompatable with Intel DX38BT Skull Trail boards.
I have talked to Intel and they are working on a newer Bios to fix the issue .
I tried rolling the bios back a couple of times with no luck..
500.00 and still can't use my card.
But this board will run your XFX 280 with no problem.
Have you contacted intell..there boards have a lifetime garranty.