I am having much the same problem on a DG33TL motherboard. I have tried two different eSATA drives (Vantec and Seagate FreeAgent Extreme) and two different eSATA cables. Both drives will work fine with a USB connection. With an eSATA connection both drives have worked very sporatically. They ONLY work if the BIOS recognizes them on boot. I have not been able to identify any conditions under which I can cause the system to reliably recognize the drives, but if it does recognize the drive it will work for a while... sometimes for an entire session... sometimes it disconnects in the middle of the session. Looking at this message board, it appears that quite a few users are having similar problems with eSATA on a wide range of Intel boards. Any help would be appreciated.