You should be able to. On the Intel motherboards, you have to enable it in the BIOS and declare which will be the primary for boot. Setup after that is the same as Extended Desktop. Some software (like MS Power Point) allows you select which display to use for output while the "program" stays on the primary display. Can't help you with the 3D but if nothing else, just click on the title bar and drag the program to your desired display.