This sounds more like a failing hardware issue (overheating perhaps) to me from your description. Compatibility issues usually (not always) will give some indication in the event logs or BSOD or crash dump files.I have the same set up you mention
CPU - Intel i7 920
RAM - 3 GB
MB - Intel DX58SO
and it came built with Windows Vista Home Preminum x64. I did an upgrade to Windows 7 Ultimate x64 with no problems. I have never experienced your issue. There have been reports of problems with some BIOS updates but not sure if they cause your problem exactly. I think I stayed on 5200 because of complaints with later versions. You might want to search this board to see what version is considered the most stable just to rule that out. Are you using SSD or Sata drives?