If you are using Win Vista or Win 7 see maybe you need to disable "USB selective suspend setting" to "Disabled" in Power Options -> USB settings.
i'm also facing the same problem of USB ports..
but not sorted out with this DISABLING..!
I'm also facing the same problem now, after using it without problems for 6 months. Sometimes Mr.Daves idea is working.( http://communities.intel.com/thread/3430;jsessionid=9EE04631501CD762B94648150146C68B.node6COM?start=15&tstart=0 )
I tried everything what Intel is recommending. But sometimes l only get blank monitor with all internal cpu parts working. NO BOOT.
I have the impression that now all ports can be used at once as some people expect. This would be a power problem since USB standards allow for hundreds of devices. Try using different ports particularly if you use monitor ports. If you haven't been changing ports the problem must be something else. The CMOS fix may be compensating for hard drive problems so you should use windows CHKDSK or the hard drive's utility to check for bad clusters.
I join the list of people with this problem besides usb ports not work nor does the sound.