There are some limitations from Operating System point of view.
You cannot boot from a volume greater than 2TB. As a test, you can create a volume smaller than 2TB and install the operating system there and then have a separate volume less than 2TB.
From Microsoft, you can have a MBR and a GPT partition on the same system which would only work if you use a 64-bit operating system.
The BIOS will only be able to Boot from a volume which uses MBR and MBR in itself has a limitation that only the first 2TB of the volume will be usable. the remaining won't be available for
The only way to use the entire volume would be to convert the Volume (the virtual raid disk) to GPT (needs compatible OS, XP 32 doesn't work with it).
All the best,