This message was posted on behalf of Intel Corporation
Thanks for your interest in our products. Just for you to know, this thread has been moved to the Intel® Optane™ Memory sub-forum.
Intel® Optane™ Memory can be paired with any SATA based drive as long as the system meets the requirements. The drive capacity is not part of these requirements and a 4TB SATA HDD should work fine.
You can learn more about the product requirements and features here:
Please let us know if there's anything else we can do for you.