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USB problems increased after the latest Windows updates were released. Please try the following steps to troubleshoot your Intel NUC.
1. Make sure the USB ports are enabled in the BIOS settings.
2. Try a BIOS Recovery Update.
Option 1 Power Button Menu
Recovery BIOS (.BIO) file link
3. You may also restore Windows back to the old version or install proper USB 3.0 drivers on your Windows 10 Creators Update system.