This message was posted on behalf of Intel Corporation
Thank you for contacting us regarding the compatibility questions that you have about the upcoming Hades Canyon NUC series; it will be more than pleasure to assist you with your inquiry.
In this case as you may know the upcoming NUCs will be:
- Intel® NUC Kit NUC8i7HNK
- Intel® NUC Kit NUC8i7HVK
Here you will find all the information and technical specs about it:
The new feature for the upcoming series will be Radeon™ RX Vega M GL graphics.
Essentially a 1080 Ti will be compatible (electronically and physically) through Thunderbolt 3 with our unit, however we do no guarantee the best performance/compatibility or full potential, your results may vary, due to the fact that the unit is no intended to work with this type of cards (GTX 1080 Ti).
As soon the product is released we should have a list of compatible/tested peripherals such as the ones listed on https://ark.intel.com for another older NUC models.
Our best recommendation is to wait until the product is fully released in order to determine the compatibility of the product with this kind of peripherals.
I hope this helps.
Thunderbolt 3 is four lane PCIe 3 while the 1080Ti supports up to sixteen lanes. First glance means limit to 25% of capacity. So no, technically you can not get full potential from a Thunderbolt connection. Real world (even games) shows loss of only a couple percent. GeForce GTX 980 PCI-Express Scaling | TechPowerUp