Unfortunately, using Librealsense in Windows is the only option for using the ZR300 with the main Windows 10 version.
The ZR300 can be used in conjunction with an Intel Joule computing board with Windows 10 IoT Core (a version of Windows for connecting to hardware via the Internet of Things).
I believe IoT Core is a stripped down version of the Windows 10 architecture though. Windows 10 IoT Enterprise claims to be a full version of Windows 10 that is equal to Windows 10 Enterprise.
I do not know if Windows 10 IoT Enterprise would work with the Joule and ZR300 though. The last time that the question was asked in Dec 2016, Intel support staff member Jose P advised "I would recommend to ask the Windows community if Windows 10 IoT Enterprise is compatible with the Intel Joule."
I remembered something else now. Although the ZR300 can be used with Librealsense, the camera is only supported for use in Ubuntu, according to the ZR300's minimum specification sheet. I'm very sorry about giving hope about using it with Librealsense in Windows. The situation surrounding what ZR300 is and isn't compatible with is somewhat confusing. :/
For using the camera with Linux, I would recommend the Intel RealSense SDK for Linux, which installs Librealsense as part of its modules.