Update: The source of this problem has actually been traced to our firewalls. While formerly reviewed and shown as Allowed in the firewall logs, the "unknown-upd" traffic is obviously being restricted in some form on our more secure user networks (such as used by our IT Department). Our less-restrictive deployment network had an any-any rule that was passing this traffic without any impacts.
Arriving at this cause was rather involved, but since we had laptops that were properly working, we were able to methodically identify and test all of the things that were "different" with their configuration and use.
Anyway, the challenge now is figuring-out how to create an appropriate application-override rule in the PAN firewalls, so that it ignores and let's pass this traffic without any impactful overhead. Unfortunately, this is more difficult than you'd think. The source and destination ports are being randomly generated (48,000-63,000 so far) and it's challenging to identify specific details upon which to base a rule. Obviously, allowing all unknown-udp would be a very bad idea. :0
I'll post an update, as progress is made.
Let me know how it goes, I would also recommend to test the latest Intel Unite® App version 22.214.171.124, this specific version fixes for 4K support and extended monitor that might address this.