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That’s is pretty cool device!
I checked the specifications and Graphics Input is USB-C (for optimum performance) or Mini DisplayPort using optional Wacom Link which seems totally compatible with Skull Canyon but Intel has not tested nor validated this device, here is the list of tested devices: http://www.intel.com/content/www/us/en/support/boards-and-kits/000020804.html
I also checked on the Wacom Community for any previous reference http://community.wacom.com/ but nothing, I would recommend that you post the same question to their community and I would also try checking with their support service.
I hope this helps,
This message was posted on behalf of Intel Corporation
My suggestion would be to contact Wacom for compatibility information. They may provide a list of tested hardware for their components.
Let's hope Wacom responds back with more information.
I understand this is an old thread, but I just built a NUC and was able to get the Wacom 16 to be the sole monitor by running the install through a HDMI compatible monitor first, and just simply switching the monitor preferences in Windows 10. It works really well, native resolution (4K? I can't remember interface is quite small) and no lag with mouse or wacom pen.