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In regard to your question, yes, you will be able to use a 2.5 hard drive, as you can confirm on the following link:
Now, just let you know that as in any other PC the hard drive might not be fully compatible with the NUC, since the laptop might be using a hard drive with different specifications as the one the NUC supports.
On the following link you will find the tested peripherals for the NUC, in there you will find some 2.5 hard drives listed:
You can always try that hard drive, it will not harm the PC, sometimes in order to make it work it needs to be formatted, a firmware update and a BIOS update might be needed as well.
Any further questions, please let me know.