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It should work, but there are limitations, and even taking all of those into account, you're kind of on your own.
512e HDD's only if you're using the onboard controller, BIOS R02.03.0004 or higher required, UEFI mode required:
If you're planning on a single 8 x 8TB RSTe RAID volume (64TB), it looks like RAID 0 is your only option -- and, honestly, it's not a great idea, since the chance of failure on RAID 0 goes up exponentially with every drive added. http://www.intel.com/content/www/us/en/support/boards-and-kits/000006143.html
You also require the appropriate C600 RAID Upgrade Key to unlock the SATA/SAS ports:
If it were me, I'd buy a hardware HBA / RAID controller, since they generally have better support for large disks / arrays. Or, I'd use Windows Server Storage Spaces with a seperate boot drive...