Make sure you are running the latest available BIOS. If you have the latest available installed, try reinstalling is using the Recovery Method (see here: BIOS Recovery Update Instructions for Intel® NUC).
You are externally powering this RAID box, right?
Hope this helps,
Yes, I have latest BIOS as well as all latest drivers hand picked from Intel site.
And yes, this is an external RAID box http://www.sansdigital.com/towerraid/tr5mb.html Worked pretty well for me for couple of years with old NUC
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Your Intel® NUC works normal with internal SSD, correct?
Honestly, I have not seen this issue before with the Intel® NUC.
Have you tried unplugging it with the system off, unplugging the power source from the NUC and the TowerRAID TR5M-B box for a few minutes, and then reconnecting everything again and turning on your system?
Have you tried contacting Sans Digital to see what they can say?
The contact support on the website you provided:
Phone: 1.800.980.1988 (For US Customers)
Try moving the system to different place, maybe there is some interference on the place you have it installed.
How do you have it connected to the NUC, could you please provide me more detailed information about this set up?