At this point, I strongly recommend to have your system up to date, with all driver and BIOS, you can download the latest BIOS version for this unit here:
Please see F7 BIOS Update Instructions for Intel® NUC
Once you have the BIOS update, Uninstall the Intel® Graphics Driver and Intel® Display HDMI/Audio Driver, then go ahead and reinstall the graphics driver, make sure you have Windows up to date as well.
Download Intel® Graphics Driver for Windows® 10 and Windows 7*/8.1* [15.40]
Please let me know how it goes.
Thank you, for the answer.
I always have the BIOS up to date, as well as Windows 10 and graphics driver, right now I try the Beta from 9/30/2016, and still have the problem.
One thing I found out yesterday: When the problem occurred, it's enough to turn off/on the monitor (Asus PB287Q) and I don't need to reset the PC.
I’m just following on this thread to ask you if your issue was resolved or if you still need further assistance. If the problem persists, could you please fill out the information from the link above when you have a chance, attach the Intel® SSU file, the Dxdiag and the report that you can get from the Report for Intel® Graphics Drivers