pretty sure it can for any hdd size, the only difference i see with "sata revisions" is transfer rate, so i imagine like usb would be backwards compatible. since that board has 6 sata ports if one is being used for internal dvd you still have 5 left to use for hdds!
now the real question is if your case has room for 5 HDDs!
This message was posted on behalf of Intel Corporation
Thought I would just check in and find out if you were able to resolve this problem, and if the information provided helps you.