On the eve of April Fools' Day, TerryCutler blogged about the Conficker worm and Intel vPro technology, posing the question "The specified item was not found." In his post, Terry was looking for community feedback on what the IT community is doing to prevent such attacks from occurring. Are you taking advantage of the use cases on your activated vPro boxes? System Defense is your best friend here - it allows you to isolate infected clients from the network. You can also use vPro technology to do things like drastically improve patch saturation - whether the systems are powered on or out of band.
I just uploaded a paper with more information on this topic - please read and see how you can protect your network from attacks from worms like the Conficker.